The .375 Raptor is intended for use in short-action rifles and offers a balance between manageable recoil and heavy-hitting performance, making it suitable for big game hunting at medium to long ranges. It is particularly favored for its versatility in hunting large and dangerous animals due to its high energy delivery and strong terminal ballistics.

The cartridge is part of the Raptor series, known for optimizing performance within compact rifle actions. It is popular among hunters seeking a potent round capable of taking down large North American game like elk, moose, and bear. Due to its specialized nature, it is not as widely available as more common cartridges, often requiring custom rifle builds or chambering.