The .375 Weatherby Magnum is a high-powered, belted, bottleneck rifle cartridge designed by Roy Weatherby in 1944. It is based on the .375 H&H Magnum case, with the neck expanded to hold a larger bullet and the shoulder blown out to increase case capacity. This design enhances the cartridge's performance, providing higher velocities and more energy compared to the .375 H&H Magnum.
Use cases for the .375 Weatherby Magnum typically involve big game hunting, particularly in Africa for species like Cape buffalo, elephant, and other large or dangerous game. It offers significant stopping power and a relatively flat trajectory, making it suitable for long-range shots on large animals. The recoil is notably vigorous, which can be challenging for some shooters. This cartridge is favored by hunters needing maximum power and penetration in a reliable and effective round.